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	Provedor de dados BJPS (2) Autor Eloy,Josimar Oliveira (2) Albuquerque,Sérgio de (1) Chorilli,Marlus (1) Ferreira,Leonardo Miziara Barboza (1) Gatti,Tiago Henrique Honorato (1) Gremião,Maria Palmira Daflon (1) Marchetti,Juliana Maldonado (1) Pavan,Fernando Rogério (1) Saraiva,Juliana (1) Silva,Isabel Cristine da (1) Mais... Palavra-chave Chaga's Disease (1) Chitosan (1) Dextran-Sulfate (1) Insulin (1) Mucoadhesion. (1) Nanoparticles (1) Poloxamer 407 (1) Sodium caprate (1) Solid dispersions (1) Ursolic acid (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2015 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Preparation, characterization and evaluation of the in vivo trypanocidal activity of ursolic acid-loaded solid dispersion with poloxamer 407 and sodium caprate BJPS Eloy,Josimar Oliveira; Saraiva,Juliana; Albuquerque,Sérgio de; Marchetti,Juliana Maldonado. Ursolic acid is a promising candidate for treatment of Chagas disease; however it has low aqueous solubility and intestinal absorption, which are both limiting factors for bioavailability. Among the strategies to enhance the solubility and dissolution of lipophilic drugs, solid dispersions are growing in popularity. In this study, we employed a mixture of the surfactants poloxamer 407 with sodium caprate to produce a solid dispersion containing ursolic acid aimed at enhancing both drug dissolution and in vivo trypanocidal activity. Compared to the physical mixture, the solid dispersion presented higher bulk density and smaller particle size. Fourier Transform Infrared Spectroscopy results showed hydrogen bonding intermolecular interactions between drug and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ursolic acid; Chaga's Disease; Solid dispersions; Poloxamer 407; Sodium caprate. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100101 Insulin-loaded polymeric mucoadhesive nanoparticles: development, characterization and cytotoxicity evaluation BJPS Gatti,Tiago Henrique Honorato; Eloy,Josimar Oliveira; Ferreira,Leonardo Miziara Barboza; Silva,Isabel Cristine da; Pavan,Fernando Rogério; Gremião,Maria Palmira Daflon; Chorilli,Marlus. Abstract Mucoadhesive nanoparticles are particularly interesting for delivery through nasal or pulmonary routes, as an approach to overcome the mucociliary clearance. Moreover, these nanoparticles are attractive for peptide and protein delivery, particularly for insulin to treat diabetes, as an alternative to conventional parenteral administration. Thus, chitosan, a cationic mucoadhesive polysaccharide found in shells of crustaceans, and the negatively-charged dextran sulfate are able to form nanoparticles through ionic condensation, representing a potential insulin carrier. Herein, chitosan/dextran sulfate nanoparticles at various ratios were prepared for insulin loading. Formulations were characterized for particle size, zeta potential, encapsulation... Tipo: Info:eu-repo/semantics/article Palavras-chave: Insulin; Chitosan; Dextran-Sulfate; Nanoparticles; Mucoadhesion.. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100623 Registros recuperados: 2 Primeira ... 1 ... Última

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