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| Silva,Pedro Henrique Reis da; Enéas,Paula Cristina Rezende; Fernandes,Christian; Pianetti,Gerson Antônio. |
| ABSTRACT Prednisone is an anti-inflammatory steroid drug widely used in clinical practice. However, no high-performance liquid chromatographic (HPLC) method has been described in the literature for the determination of prednisone in capsules until now. Thus, an HPLC method was developed using a C18 (250x4.0, 5 µm) column, with methanol:water (70:30) as mobile phase at a flow rate of 1 mL/min and detection at 240 nm. The developed method was validated following current Brazilian legislation. Additionally, linearity was assessed by evaluating the assumptions of normality, homoscedasticity, and independency of residuals, and the fit to the linear model. The method showed linearity (r2>0.99) over the range of 14.0-26.0 µg/mL, selectivity, precision... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Prednisone; Capsules; High performance liquid chromatography/validation; Linearity assessment.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200624 |
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| Enéas,Paula Cristina Rezende; Oliveira,Renata Barbosa de; Pianetti,Gerson Antônio. |
| Oxcarbazepine (OXC) is an important anticonvulsant and mood stabilizing drug. A pharmacopoeial monograph for OXC is not yet available and therefore the development and validation of a new analytical method for quantification of this drug is essential. In the present study, a UV spectrophotometric method for the determination of OXC was developed. The various parameters, such as linearity, precision, accuracy and specificity, were studied according to International Conference on Harmonization Guidelines. Batches of 150 mg OXC capsules were prepared and analyzed using the validated UV method. The formulations were also evaluated for parameters including drug-excipient compatibility, flowability, uniformity of weight, disintegration time, assay, uniformity of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Oxcarbazepine/quantitative analysis; Anticonvulsants/quantitative analysis; UV spectrophotometric/method validation; Capsules/dissolution. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200013 |
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| Costa,André Lima de Oliveira; Enéas,Paula Cristina Rezende; Miranda,Tiago Assis; Mingoti,Sueli Aparecida; Soares,Cristina Duarte Vianna; Pianetti,Gerson Antônio. |
| Mycophenolate mofetil (MMF) and mycophenolate sodium (MPS) are an ester and a salt of mycophenolic acid. They have different kinetic in vivo characteristics due to differences in molecular structures, physicochemical properties and formulations administered. In this study, dissolution profiles of reference products were tested in different media to evaluate the effect of pH, kinetic dissolution and the best statistical model that can be used to predict the release of both drugs. The drug release was determined by using a validated ultraviolet spectrophotometry method, λ 250 nm. The method showed to be selective, linear, precise and accurate for MMF in 0.1 M HCl and MPS in sodium phosphate buffer pH 6.8. Dissolution kinetics models of zero order, first... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mycophenolate sodium; Mycophenolate mofetil; Dissolution profiles; Weibull kinetics. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200013 |
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