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	Provedor de dados Nature Precedings (2) Autor Eric M. Ostertag (2) Andrew L. Varnell (1) Andrew L. Varnell (1) Donald C. Cooper (1) Donald C. Cooper (1) Jun-Gang Wang (1) Kristin C. Rasmus (1) Kurt R. Illig (1) William D. Klipec (1) Mais... Palavra-chave Genetics & Genomics (2) Neuroscience (2) Pharmacology (1) Tipo do documento Manuscript (2) Ano 2011 (2) País United Kingdom (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Sociability is decreased following deletion of the _trpc4_ gene Nature Precedings Kristin C. Rasmus; Jun-Gang Wang; Andrew L. Varnell; Eric M. Ostertag; Donald C. Cooper. Shyness and social anxiety are predominant features of some psychiatric disorders including autism, schizophrenia, anxiety and depression. Understanding the cellular and molecular determinants of sociability may reveal therapeutic approaches to treat individuals with these disorders and improve their quality of life. Previous experiments from our laboratory have identified selective mRNA and protein expression of a nonselective cation channel known as the canonical transient receptor potential channel 4 (TRPC4s) in brain regions implicated in emotional regulation and anxiety. TRPC4 is highly expressed in the corticolimbic regions of the mammalian brain. We hypothesized that robust corticolimbic expression of TRPC4 may regulate the brain’s... Tipo: Manuscript Palavras-chave: Genetics & Genomics; Neuroscience. Ano: 2011 URL: http://precedings.nature.com/documents/6367/version/1 TRPC4 ion channel protein is selectively expressed in a subpopulation of dopamine neurons in the ventral tegmental area Nature Precedings Kurt R. Illig; Andrew L. Varnell; Eric M. Ostertag; William D. Klipec; Donald C. Cooper. The nonselective cation channel TRPC4 has been shown to be present in high abundance in the corticolimbic regions of the brain and play a pivotal role in modulating cellular excitability due to their involvement in intracellular Ca^2+^ regulation. Recently we reported their involvement in socialization and regulating anxiety-like behaviors in rats. Given the important role for dopamine in modulating emotions involved in social anxiety we investigated whether TRPC4 protein and mRNA was found on dopaminergic neurons of the ventral tegmental area (VTA). Using emulsion autoradiography we found that TRPC4 mRNA is indeed present in the VTA and the substantia nigra. Additionally, immunohistochemistry verified it’s presence on a subpopulation of... Tipo: Manuscript Palavras-chave: Genetics & Genomics; Neuroscience; Pharmacology. Ano: 2011 URL: http://precedings.nature.com/documents/6577/version/1 Registros recuperados: 2 Primeira ... 1 ... Última

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