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Characterization and stability studies of emulsion systems containing pumice BJPS
Estanqueiro,Marilene; Conceição,Jaime; Amaral,Maria Helena; Santos,Delfim; Silva,João Baptista; Lobo,José Manuel Sousa.
Emulsions are the most common form of skin care products. However, these systems may exhibit some instability. Therefore, when developing emulsions for topical application it is interesting to verify whether they have suitable physical and mechanical characteristics and further assess their stability. The aim of this work was to study the stability of emulsion systems, which varied in the proportion of the emulsifying agent cetearyl alcohol (and) sodium lauryl sulfate (and) sodium cetearyl sulfate (LSX), the nature of the oily phase (decyl oleate, cyclomethicone or dimethicone) and the presence or absence of pumice (5% w/w). While maintaining the samples at room temperature, rheology studies, texture analysis and microscopic observation of formulations...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Emulsions/topical use/stability study; Emulsions/topical use/characterization; Pumice/presence in emulsions; Emulsions/texture; Emulsions/rheology; Emulsions/spreadability.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200361
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Use of solid dispersions to increase stability of dithranol in topical formulations BJPS
Estanqueiro,Marilene; Conceição,Jaime; Amaral,Maria Helena; Lobo,José Manuel Sousa.
The present study was planned to improve the stability of dithranol using solid dispersions (SD). Two different SD at a 1:9 ratio of dithranol/excipient were prepared: one of them using glyceryl behenate as excipient and the other using a mixture of argan oil with stearic acid (1:8 ratio) as excipient. Pure dithranol and SD of dithranol were incorporated in an oil-in-water cream and in a hydrophobic ointment in a drug/dermatological base ratio of 1:10. The physical and mechanical properties of semisolid formulations incorporating the pure drug and the developed SD were evaluated through rheological and textural analysis. To evaluate the stability, L*a*b* color space parameters of SD and semisolid formulations, and pH of hydrophilic formulations were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dithranol/stability; Topical formulations/development; Solid dispersions/preparation; Stearic acid; Glyceryl behenate; Argan oil.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300583
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