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| GIOVANELLA,FRANCIANNE; FERREIRA,GABRIELA K.; PRÁ,SAMIRA D.T. DE; CARVALHO-SILVA,MILENA; GOMES,LARA M.; SCAINI,GISELLI; GONÇALVES,RENATA C.; MICHELS,MONIQUE; GALANT,LETÍCIA S.; LONGARETTI,LUIZA M.; DAJORI,ANA LUIZA; ANDRADE,VANESSA M.; DAL-PIZZOL,FELIPE; STRECK,EMILIO L.; SOUZA,RENAN P. DE. |
| Primaquine and chloroquine are used for the treatment of malaria; evidence from the literature suggests that these drugs may induce oxidative stress. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA damage in brain, liver and kidney of rats after 7, 14 and 21 days of administration. Our results demonstrated that primaquine causes DNA damage in brain after 7, 14 and 21 days, and in liver after 7 and 14 days. Moreover, primaquine increases TBARS levels in the kidney and protein carbonyls in the brain after 14 days, and decreases protein carbonyls in the liver after 7 days. Whereas chloroquine causes DNA damage in the kidney after 7 and 14 days, and in the liver after 14 and 21 days, increases TBARS levels in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Primaquine; Chloroquine; Oxidative damage; DNA damage; Antimalarial drugs. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301487 |
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| TEODORAK,BRENA P.; FERREIRA,GABRIELA K.; SCAINI,GISELLI; WESSLER,LETÍCIA B.; HEYLMANN,ALEXANDRA S.; DEROZA,PEDRO; VALVASSORI,SAMIRA S.; ZUGNO,ALEXANDRA I.; QUEVEDO,JOÃO; STRECK,EMILIO L.. |
| Fenproporex is the second most commonly amphetamine-based anorectic consumed worldwide; this drug is rapidly converted into amphetamine, in vivo, and acts by increasing dopamine levels in the synaptic cleft. Considering that fenproporex effects on the central nervous system are still poorly known and that acetylcholinesterase is a regulatory enzyme which is involved in cholinergic synapses and may indirectly modulate the release of dopamine, the present study investigated the effects of acute administration of fenproporex on acetylcholinesterase activity in brain of young rats. Young male Wistar rats received a single injection of fenproporex (6.25, 12.5 or 25mg/kg i.p.) or vehicle (2% Tween 80). Two hours after the injection, the rats were killed by... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acetylcholinesterase; Amphetamine; Dopamine; Fenproporex. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301389 |
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