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| OLIVEIRA,JADE DE; STRALIOTTO,MARCOS R.; MANCINI,GIANNI; FIGUEIREDO,CLAUDIA P.; BRAGA,ANTÔNIO L.; TEIXEIRA,JOÃO B.R.; BEM,ANDREZA F.. |
| ABSTRACT Oxidation of low-density lipoprotein (LDL) has been strongly suggested to play a significant role in the pathogenesis of atherosclerosis. Thus, reducing LDL oxidation is a potential approach to decrease the risk of the atherosclerosis. Organoselenium compounds have demonstrated promising atheroprotective properties in experimental models. Herein, we tested the in vitro atheroprotective capability of a modified organoselenium compound, Compound HBD, in protecting isolated LDL from oxidation as well as foam cells formation. Moreover, the glutathione peroxidase (GPx)-like activity of Compound HBD was analyzed in order to explore the mechanisms related to the above-mentioned protective effects. The Compound HBD in a concentration-dependent manner... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Atherosclerosis; Compound HBD; Foam cell; GPx-like activity; LDL oxidation; Organoselenium compounds. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501953 |
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| FIGUEIREDO,CLAUDIA P.; FERREIRA,NATALIA C.; PASSOS,GISELLE F.; COSTA,ROBSON DA; NEVES,FERNANDA S.; MACHADO,CLARICE S.C.; MASCARELLO,ALESSANDRA; CHIARADIA-DELATORRE,LOUISE D.; NEUENFELDT,PATRÍCIA D.; NUNES,RICARDO J.; CORDEIRO,YRAIMA. |
| An altered form of the cellular prion protein, the PrPScor PrPRes, is implicated in the occurrence of the still untreatable transmissible spongiform encephalopathies. We have previously synthesized and characterized aromatic compounds that inhibit protease-resistant prion protein (PrPRes) accumulation in scrapie-infected cells. These compounds belong to different chemical classes, including acylhydrazones, chalcones and oxadiazoles. Some of the active compounds were non-toxic to neuroblastoma cells in culture and seem to possess drugable properties, since they are in agreement with the Lipinski´s rule of 5 and present desirable pharmacokinetic profiles as predicted in silico. Before the evaluation of the in vivo efficacy of the aromatic compounds in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Prion; Acute toxicity; Organic compound; Drug safety; Scrapie; Pharmacokinetics. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301421 |
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