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| Magina,Michele Debiasi Alberton; Pietrovski,Evelise Fernades; Gomig,Franciane; Falkenberg,Daniel de Barcellos; Cabrini,Daniela Almeida; Otuki,Michel Fleith; Pizzollati,Moacir Geraldo; Brighente,Inês Maria Costa. |
| In order to verify the topical antiinflammatory effect of epicuticular wax from leaves of Eugenia beaurepaireana, it was tested in mice croton oil-induced inflammation. Our findings show that topical application of Eugenia beaurepaireana epicuticular wax was significantly active in inhibiting both oedema (Inhibitory dose 50 % (ID50) = 0.31 (0.26 - 0.39) mg.ear -1, inhibition = 79 ± 6 %) and tissue myeloperoxidase activity (indicative of polymorphonuclear leukocytes influx) (ID50 =0.34 (0.20 - 0.41) mg.ear -1, inhibition = 77 ± 4 %) in mice ear treated with croton oil. Two main compounds were detected on epicuticular wax of E. beaurepaireana. These compounds were identified as α- and β-amyrin by flame ionization detection (GC-FID) and spectroscopic methods... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Eugenia beaurepaireana/pharmacognosy; Α-amyrin; Β-amyrin; Epicuticular wax/antiinflammatory activity; Ear oedema/experimental study. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000100021 |
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