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Effect of naringerin on biochemical parameters in the streptozotocin-induced diabetic rats BABT
Fernandes,Ana Angélica Henrique; Novelli,Ethel Lourenzi Barbosa; Fernandes Junior,Ary; Galhardi,Cristiano Machado.
Amongst the numerous co-adjuvant therapies which could influence the incidence and progression of diabetic complications, antioxidants and flavonoids are currently being tested in clinical trials. We investigated the effect of naringerin on biochemical parameters in streptozotocin-induced (STZ - 60 mg/kg, i.p.) diabetic rats. Male rats were divided into four groups: G1: untreated controls; G2: normal rats receiving naringerin; G3: untreated diabetics; G4: diabetics rats receiving naringerin. The naringerin (50mg/kg, i.p,) decreased the hyperglycaemia and hyperlipidaemia associated with STZ-diabetes. The concentrations of serum insulin in treated diabetic rats tended to be increased. Naringerin treatment prevents STZ-induced changes in the activities of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Naringerin; Hypoglycaemic activity; Streptozotocin; Diabetes mellitus; Aminotransferases; Hepatic; Cardiac tissues.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000100007
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Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin BABT
Almeida,Danielle Ayr Tavares de; Braga,Camila Pereira; Novelli,Ethel Lourenzi Barbosa; Fernandes,Ana Angélica Henrique.
The present study investigated the effect of supplementation of vitamin E on streptozotocin (STZ)-induced diabetic rats by measuring blood glucose, changes in body weight, food and water intake, lipid profile, serum urea and creatinine level, and antioxidant enzyme activity. Male Wistar rats were divided into four groups: control rats (GI); rats receiving vitamin E (GII); STZ-induced diabetic rats (GIII) and STZ-induced diabetic rats treated with vitamin E (GIV). Vitamin E reduced (p<0.05) blood glucose and urea, improved the lipid profile (decreased the serum levels of total cholesterol, LDL cholesterol, VLDL cholesterol and triacylglycerols, and increased HDL cholesterol) and increased total protein in STZ-induced diabetic rats (GIV). Vitamin...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Vitamin E; Lipid profile; Oxidative stress; STZ.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000400007
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