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| Klautau-Guimarães,Maria de Nazare; DAscenção,Renata; Caldart,Fabiana A.; Grisolia,Cesar K.; Souza,Jurandir R. de; Barbosa,Antonio C.; Cordeiro,Célia M.T.; Ferrari,Iris. |
| We investigated Individual differences in susceptibility to methylmercury (MeHg) contamination and its relationship with polymorphisms of the detoxifying enzyme glutathione S-transferase (GST). In Brazil, some Amerindian tribes from the Amazon region have an increased level of mercury in their hair. Samples of hair and blood were taken from inhabitants of two villages in the Kayabi and Munduruku Amerindian communities to investigate mercury levels in association with genetic polymorphism of GSTs. Other molecular biological markers were also studied, such as hemoglobin, haptoglobin and glucose 6-phosphate dehydrogenase (G-6-PDH). Higher levels of mercury contamination were found in the Kayabi villagers, who had a null genotype (GSTM1 0/0, also denominated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amerindian; Genetic polymorphism; Glutathione S-transferase; Mercury. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000500027 |
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| Waldrigues,Aldo; Ferrari,Iris; Faustino Neto,Antonio. |
| Resumo Foram estudadas citogeneticamente duas espécies de aves da Família Cuculidae: Playa cayana (Phaenicophaeinae) e Crotophaga major (Crotophoginae) capturadas na região de Manaus (AM). Os cromossomos foram preparados a partir de células da medula óssea, em cultura de curta duração (4 horas). A análise cariotípica foi realizada por métodos convencionais, obtendo-se dados numéricos, morfológicos e métricos dos cromossomos destas duas espécies. A classificação dos cromossomos obedeceu à proposição de Levan et al. (1964). Os cromossomos foram divididos em três grupos: dois de macrocromossomos (grupos A e B) e um de microcromossomos (grupo C). Foram considerados como macrocromossomos, todos aqueles que apresentaram Proporção Relativa maior ou igual a 4%.... |
| Ano: 1983 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59671983000100037 |
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| Grisolia,Cesar Koppe; Ferrari,Iris. |
| The herbicide metolachlor was evaluated for genotoxic potential. Metolachlor did not induce micronuclei in mice, however at 40 mg/kg it significantly decreased the percentage of polychromatic erythrocytes, which is a cytotoxic effect. Metolachlor did not induce chromosomal aberrations in human lymphocytes in vitro, but 2.0 mug/ml culture medium resulted in cytotoxicity, decreasing the mitotic index significantly. The indirect exposure test was carried out by adding plasma from metolachlor-pretreated rats to the human lymphocyte cultures. There was no indication of clastogenicity by metolachlor metabolites. On the other hand, plasma of cyclophosphamide-pretreated rats had a significant clastogenic effect |
| Tipo: Info:eu-repo/semantics/article |
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| Ano: 1997 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551997000300009 |
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