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| Santos,Mariane Gonçalves; Vitor,Ricardo Vilela; Nakamura,Maurício Gustavo; Morelini,Luana de Souza; Ferreira,Rafaela Scalco; Paiva,Alexandre Giusti; Azevedo,Luciana; Marques,Vanessa Bergamin Boralli; Martins,Isarita; Figueiredo,Eduardo Costa. |
| Organophosphates (OPs) are widely used as pesticides, and its urinary metabolites as well as the blood cholinesterases (ChEs) activity have been reported as possible biomarkers for the assessment of this pesticide exposure. Moreover, the OPs can induce mutagenesis, and the bone marrow micronucleus test is an efficient way to assess this chromosomal damage. This paper reports a study carried out to verify the correlation among the disulfoton exposure, blood ChEs activity, urinary diethyl thiophosphate (DETP), and diethyl dithiophosphate (DEDTP), as well as micronucleated polychromatic erythrocytes (MNPCEs) frequency. Four groups of rats (n=12) were exposed to disulfoton at 0, 2.8, 4.7, and 6.6 mg kg-1 body weight. The blood ChEs activity, urinary DETP and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pesticides/exposure study; Organophosphate/exposure study; Disulfoton/exposure; Dialkyl phosphate/urinary excretion; Blood cholinesterase; Micronucleated polychromatic erythrocytes/frequency. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100016 |
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