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Registros recuperados: 2
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Analysis of the evidence of efficacy and safety of over-the-counter cough medications registered in Brazil BJPS
Reis,Adriano Max Moreira; Figueras,Albert.
The objective of this study was to analyze the level of evidence regarding the efficacy, effectiveness and safety of over-the-counter (OTC) cough medications registered in Brazil. The National Health Surveillance Agency database was used to identify the drugs. Clinical trials, systematic reviews, meta-analyses, and studies on safety were searched on the Medline baseline, the Cochrane Library and SIETES (System of Essential Information in Therapeutics and Health; database in Spanish). Most drugs (62.5%) were sold as a fixed-dose combination of two or more drugs. Randomized clinical trials were found for only three drugs: bromhexine, dextromethorphan and guaifenesin. No clinical trials were found for fixed-dose combinations. Systematic reviews on Cochrane...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drugs/utilization studies; Cough; Drugs/nonprescription; Pharmacovigilance; Pharmacoepidemiology.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000100016
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Nonadherence to treatment recommendations is a factor contributing to the clinical failure of daptomycin: Cohort study in Brazil BJPS
Martins,Tathiana Silva de Souza; Figueras,Albert; Souza,Luana dos Reis de; Santos,Keila Cristina Oliveira dos; Oliveira,Elaine Machado de; Secoli,Silvia Regina.
To evaluate the clinical outcomes of daptomycin therapy and adherence to treatment recommendations, a retrospective cohort study was conducted with patients that received daptomycin during the period of the study. The adherence and nonadherence to clinical guidelines were assessed through organism identification, dose and time of treatment, management of bacteremia, and vancomycin treatment failure. A multiple logistic regression model analyzed the association between independent variables and clinical success (dependent variable), considering 5% of statistical significance. The study presented 52 patients who received daptomycin for the treatment of bacteremia (21.1%) or infections (osteomyelitis [63.5%], synovial fluid [15.4%]). Most patients (86.5%)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Daptomycin; Post marketing; Gram-positive bacterial infections; Orthopedic.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100583
Registros recuperados: 2
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