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Parasympathetic dysfunction is associated with insulin resistance in fructose-fed female rats BJMBR
Brito,J.O.; Ponciano,K.; Figueroa,D.; Bernardes,N.; Sanches,Í.C.; Irigoyen,M.C.; De Angelis,K..
The objective of the present study was to identify metabolic, cardiovascular and autonomic changes induced by fructose overload administered in the drinking water of rats for 8 weeks. Female Wistar rats (200-220 g) were divided into 2 groups: control (N = 8) and fructose-fed rats (N = 5; 100 mg/L fructose in drinking water for 8 weeks). The autonomic control of heart rate was evaluated by pharmacological blockade using atropine (3 mg/kg) and propranolol (4 mg/kg). The animals were submitted to an intravenous insulin tolerance test (ITT) and to blood glucose measurement. The fructose overload induced a significant increase in body weight (~10%) and in fasting glycemia (~28%). The rate constant of glucose disappearance (KITT) during ITT was lower in...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Female rats; Fructose; Blood pressure; Insulin resistance; Parasympathetic nervous system.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000900010
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