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Short-term high-fat diet affects macrophages inflammatory response, early signs of a long-term problem 60
Santos,Ed Wilson; Oliveira,Dalila Cunha; Hastreiter,Araceli; Silva,Graziela Batista; Beltran,Jackeline Soares de Oliveira; Rogero,Marcelo Macedo; Fock,Ricardo Ambrósio; Borelli,Primavera.
Obesity is a chronic inflammatory disease that affects millions of people worldwide. Most studies observe the effects of a high-fat diet (HFD) in 10-12 weeks. This work investigated the effects induced by a HFD administered for 6 weeks on the nutritional status of mice and some aspects of the inflammatory response in mouse peritoneal macrophages. Male Swiss Webster mice, 2-3 months of age, were fed a control diet or HFD for 6 weeks. After this period, the mice were euthanized, and peritoneal macrophages were collected for immunoassays and assessment of biochemical parameters. A HFD was associated with increased cholesterol, insulin resistance, C-reactive protein (CRP), leptin, and serum resistin levels. Lipopolysaccharide (LPS)- stimulated adipocyte...
Tipo: Info:eu-repo/semantics/article Palavras-chave: High-fat diet/study; Mice; Macrophages; Metabolic syndrome; NF-kB..
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100548
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Dentistry 60
Fock,Ricardo Ambrósio.
Tipo: Info:eu-repo/semantics/review
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100025
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The influence of protein malnutrition on the production of GM-CSF and M-CSF by macrophages 60
Oliveira,Dalila Cunha de; Hastreiter,Araceli Aparecida; Borelli,Primavera; Fock,Ricardo Ambrósio.
ABSTRACT It is well established that protein malnutrition (PM) impairs immune defenses and increases susceptibility to infection. Macrophages are cells that play a central role in innate immunity, constituting one of the first barriers against infections. Macrophages produce several soluble factors, including cytokines and growth factors, important to the immune response. Among those growth factors, granulocyte-macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF). GM-CSF and M-CSF are important to monocyte and macrophage development and stimulation of the immune response process. Knowing the importance of GM-CSF and M-CSF, we sought to investigate the influence of PM on macrophage production of these growth...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Protein malnutrition; Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF); Macrophage Colony-Stimulating Factor (M-CSF).
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300375
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