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Over-expression of cyclooxygenase-2 in endoscopic biopsies of ectopic gastric mucosa BJMBR
Martins,F.P.; Artigiani Neto,R.; Oshima,C.T.; Costa,P.P. da; Forones,N.M.; Ferrari,A.P..
Ectopic gastric mucosa (EGM) is considered to be a congenital condition. Rare cases of adenocarcinoma have been described. There are no data justifying regular biopsies or follow-up. Cyclooxygenase-2 (COX-2) is a protein involved in gastrointestinal tumor development by inhibiting apoptosis and regulating angiogenesis. The aim of this prospective study was to evaluate COX-2 expression in EGM and compare it with normal tissue and Barrett's esophagus. We evaluated 1327 patients. Biopsies were taken from the inlet patch for histological evaluation and from the gastric antrum to assess Helicobacter pylori infection. Biopsies taken from normal esophageal, gastric antrum and body mucosa and Barrett's esophagus were retrieved from a tissue bank. EGM biopsies were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Endoscopy; Ectopic gastric mucosa; Cyclooxygenase-2; Barrett's esophagus; Gastric biopsies.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100005
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Immunoexpression of cyclooxygenase-1 and -2 in ulcerative colitis BJMBR
Paiotti,A.P.R.; Artigiani Neto,R.; Forones,N.M.; Oshima,C.T.F.; Miszputen,S.J.; Franco,M..
Ulcerative colitis (UC) is a disease of the colon and rectum characterized by a nonspecific chronic inflammation mediated by the concerted response of cellular and humoral events. Prostaglandins are synthesized by cyclooxygenase (COX)-1 and -2 and exhibit both pro- and anti-inflammatory activity. To evaluate COX-1 and COX-2 immunoexpression in 42 cases of UC and to correlate it with clinicopathological parameters, COX-1 and COX-2 expression was investigated by the immunohistochemistry method. Only patients with all pertinent clinical and evolutive data as well as with adequate biopsy material were included in the study. Fifteen samples of colorectal adenocarcinoma and 14 of large bowel with no histological changes were used for positive and negative...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ulcerative colitis; Cyclooxygenases; Prostaglandins; Immunohistochemistry.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700004
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Laminin concentration in ascites of patients with hepatic cirrhosis and peritoneal carcinomatosis BJMBR
Catarino,R.M.; Lopes,J.D.; Forones,N.M.; Parise,E.R..
Laminin levels in ascitic fluid have been proposed as a marker for neoplastic ascites. We compared the concentration of laminin in serum and in ascitic fluid from patients with hepatic cirrhosis and peritoneal carcinomatosis and assessed the diagnostic value of serum laminin levels in differentiating neoplastic from benign ascites. Laminin concentrations were determined by ELISA with antibodies against laminin extracted from the human placenta, in patients with ascites due to peritoneal carcinomatosis (N = 20) and hepatic cirrhosis (N = 33). Patients with infected or hemorrhagic ascites were excluded. The receiver operating characteristic curve was used to determine the sensitivity and specificity of serum laminin for the diagnosis of neoplastic ascites....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ascites laminin; Serum laminin; Peritoneal carcinomatosis; Cirrhosis.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000200016
Registros recuperados: 3
Primeira ... 1 ... Última
 

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