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Article Molecular analysis of three FUT3 gene single nucleotide polymorphisms and their relationship with the lewis erythrocytary phenotype in a human population of japanese-ancestry living in Tomé Açu, a town in the Brazilian Amazon Genet. Mol. Biol.
Francez,Pablo Abdon da Costa; Corvelo,Tereza Cristina de Oliveira; Silva,Flávio Ricardo Leal da; Santos,Sidney Emanuel Batista dos.
The Lewis blood group system involves two major antigens, Leª and Le b. Their antigenic determinants are not primary gene products but are synthesized by the transfer of sugar subunits to a precursory chain by a specific enzyme which is the product of the FUT3 gene (Lewis gene). The presence of three FUT3 gene single nucleotide polymorphisms (SNPs) (59T > G; 508G > A and 1067T > A) was related to the Lewis phenotype of erythrocytes from 185 individuals of Japanese ancestry living in the town of Tomé-Açu in the Brazilian Amazon region. This relationship was detected using a serological hemagglutination test and the Dot-ELISA assay along with the molecular technique PCR-RFLP. We found that the three SNPs investigated in this study only accounted for...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lewis blood groups; FUT3; Japanese; PCR-RFLPs; SNPs.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000300002
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Haplotype diversity of 17 Y-str loci in an admixed population from the Brazilian Amazon Genet. Mol. Biol.
Francez,Pablo Abdon da Costa; Ramos,Luiz Patrick Vidal; Palha,Teresinha de Jesus Brabo Ferreira; Santos,Sidney Emanuel Batista dos.
The allelic and haplotype frequencies of 17 Y-STR loci most commonly used in forensic testing were estimated in a sample of 138 unrelated healthy males from Macapá, in the northern Amazon region of Brazil. The average gene diversity was 0.6554 ± 0.3315. 134 haplotypes of the 17 loci were observed, 130 of them unique and four present in two individuals each. The haplotype diversity index was 0.9996 + 0.0009, with the most frequent haplogroups being R1b (52.2%), E1b1b (11.6%), J2 (10.1%) and Q (7.2%). Most haplogroups of this population belonged to European male lineages (89.2%), followed by Amerindian (7.2%) and African (3.6%) lineages.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amazon population; Forensic genetics; Haplogroups; Y-haplotypes; Y-STR.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000100006
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Allelic frequencies and statistical data obtained from 12 codis STR loci in an admixed population of the Brazilian Amazon Genet. Mol. Biol.
Francez,Pablo Abdon da Costa; Rodrigues,Elzemar Martins Ribeiro; Frazão,Gleycianne Furtado; Borges,Nathalia Danielly dos Reis; Santos,Sidney Emanuel Batista dos.
The allelic frequencies of 12 short tandem repeat loci were obtained from a sample of 307 unrelated individuals living in Macapá, a city in the northern Amazon region, Brazil. These loci are the most commonly used in forensics and paternity testing. Based on the allele frequency obtained for the population of Macapá, we estimated an interethnic admixture for the three parental groups (European, Native American and African) of, respectively, 46%, 35% and 19%. Comparing these allele frequencies with those of other Brazilian populations and of the Iberian Peninsula population, no significant distances were observed. The interpopulation genetic distances (F ST coefficients) to the present database ranged from F ST = 0.0016 between Macapá and Belém to F ST =...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Allelic frequencies; Brazilian Amazon population; Interethnic admixture.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100007
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