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Phenobarbital loaded microemulsion: development, kinetic release and quality control BJPS
Figueiredo,Kayo Alves; Neves,Jamilly Kelly Oliveira; Silva,José Alexsandro da; Freitas,Rivelilson Mendes de; Carvalho,André Luis Menezes.
ABSTRACT This study aimed to obtain and characterize a microemulsion (ME) containing phenobarbital (PB). The PB was incorporated in the proportion of 5% and 10% in a microemulsion system containing Labrasol(r), ethanol, isopropyl myristate and purified water. The physicochemical characterization was performed and the primary stability of the ME was evaluated. An analytical method was developed using spectrophotometry in UV  = 242 nm. The kinetics of the in vitro release (Franz model) of the ME and the emulsion (EM) containing PB was evaluated. The incorporation of PB into ME at concentrations of 5 and 10% did not change pH and resistance to centrifugation. There was an increase in particle size, a decrease of conductivity and a change in the refractive...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Microemulsion/physicochemical characterization; Microemulsion/In vitro release; Phenobarbital/microemulsion system/evaluation; Nanotechnology.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000200251
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The effect of natural and organophilic palygorskite on skin wound healing in rats BJPS
Silva,Mirna Luciano de Gois da; Fortes,Amanda Campos; Tomé,Adriana da Rocha; Silva Filho,Edson Cavalcanti da; Freitas,Rivelilson Mendes de; Soares-Sobrinho,José Lamartine; Leite,Cleide Maria da Silva; Soares,Mônica Felts de La Roca.
In view of growing interest in natural treatments, clays would appear to be a good alternative for speeding up the healing process during the treatment of wounds. Of the various clays, palygorskite, a clay from the Brazilian State of Piauí, composed of silicon and aluminum, has shown itself to be pharmaceutically useful as a healing agent. The aim of this article is to evaluate the effect on the healing of wounds of Piauí palygorskite, both in its natural state and when organophilic, by way of comparative analysis of macroscopic and histological tests on skin wounds in adult male and female two-month-old Wistar rats. To this end, a circular trichotomy of the dorsal cornus of the rats was carried out to confirm the effects of treatments involving 0.9%...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Attapulgite/healing agent; Palygorskite/healing agent; Healing/experimental study; Skin wounds/healing; Skin wounds/experimental study.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400012
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