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	Provedor de dados Nature Precedings (1) Autor Alan Okada (1) Fumiko Ono (1) Hidechika Okada (1) Masaki Imai (1) Noriko Okada (1) Palavra-chave Biotechnology (1) Immunology (1) Pharmacology (1) Tipo do documento Manuscript (1) Ano 2011 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última HMGB1 release by C5a anaphylatoxin is an effective target for sepsis treatment Nature Precedings Hidechika Okada; Noriko Okada; Masaki Imai; Alan Okada; Fumiko Ono. Antibodies to C5a have proven to be effective in treating experimental septic primate models. A 17 amino acid peptide (ASGAPAPGPAGPLRPMF) named PepA binds to C5a and prevents complement-mediated lethal shock in rats. AcPepA harboring an acetyl group at the N-terminal alanine showed increased inhibitory activity against C5a. Cynomolgus monkeys destined to expire from a lethal dose of bacterial endotoxin (4mg/kg) were rescued by intravenous administration of AcPepA. AcPepA could have interfered with the ability of C5a to stimulate C5L2 which is responsible for HMGB1 release and stimulation of TLR4 as an endogeneous ligand with LPS behavior. The suppression of HMGB1 release by AcPepA administration to LPS-shock monkeys is likely responsible for rescuing the... Tipo: Manuscript Palavras-chave: Biotechnology; Immunology; Pharmacology. Ano: 2011 URL: http://precedings.nature.com/documents/5727/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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