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	Provedor de dados Genet. Mol. Biol. (2) Autor Fuu-Jen,Tsai (2) Chang-Hai,Tsai (1) Chao-Hsiang,Chang (1) Cheng-Chieh,Lin (1) Chi-Chen,Chang (1) Hsi-Chin,Wu (1) Huey-Yi,Chen (1) Lian-Shun,Yeh (1) Wen-Chi,Chen (1) Yao-Yuan,Hsieh (1) Mais... Palavra-chave Single nucleotide polymorphism (2) Bladder cancer (1) CYP17 (1) Cytochrome P450c17 (1) Leiomyoma (1) Urokinase (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2004 (1) 2002 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Urokinase gene 3'-UTR T/C polymorphism is not associated with bladder cancer Genet. Mol. Biol. Hsi-Chin,Wu; Chao-Hsiang,Chang; Wen-Chi,Chen; Huey-Yi,Chen; Fuu-Jen,Tsai. Urokinase degrades basement proteins and is hypothesized to play a role in cancer progression. We investigated the hypothesis of C/T polymorphism in the 3'-untranslated region (3'-UTR) of the urokinase gene being associated with the development of bladder cancer. Such an association seems unlikely, since the genotype distributions in 114 bladder cancer patients did not differ from those of 105 controls. Tipo: Info:eu-repo/semantics/article Palavras-chave: Urokinase; Bladder cancer; Single nucleotide polymorphism. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000100003 Cytochrome P450c17alpha (CYP17) gene polymorphism is not associated with leiomyoma susceptibility Genet. Mol. Biol. Yao-Yuan,Hsieh; Fuu-Jen,Tsai; Chi-Chen,Chang; Chang-Hai,Tsai; Cheng-Chieh,Lin; Lian-Shun,Yeh. Estrogen plays a role in the pathogenesis of leiomyoma. The CYP17 gene codes for the cytochrome P450c17alpha enzyme, which is involved in the biosynthesis of estrogen. Our aim was to investigate if CYP17 polymorphism could be a useful marker to predict the susceptibility to leiomyoma. Our sample of female subjects was divided into two groups: (1) with leiomyoma (n = 159); (2) without leiomyoma (n = 128). A 169-bp fragment encompassing the A1/A2 polymorphic site of the CYP17 gene was amplified by polymerase chain reaction (PCR), restricted by enzyme MspA1I and electrophored on agarose gel. Genotypes and allelic frequencies for this polymorphism in both groups were compared. There was no significant difference between the two groups regarding the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cytochrome P450c17; CYP17; Leiomyoma; Single nucleotide polymorphism. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000400002 Registros recuperados: 2 Primeira ... 1 ... Última

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