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Cytotoxicity and trypanocidal activity of nifurtimox encapsulated in ethylcyanoacrylate nanoparticles Biol. Res.
SÁNCHEZ,GITTITH; CUELLAR,DANIELA; ZULANTAY,INES; GAJARDO,MARTA; GONZÁLEZ-MARTIN,GUILLERMO.
The aim of the present study was to study the trypanocidal activity of nanoparticles loaded with nifurtimox in comparison with the free drug against Trypanosoma cruzi, responsible for Chagas' disease. Ethylcyanoacrylate nanoparticles acted as the delivery system into cells. As the obligate replicative intracellular form is amastigote, in vitro studies were performed on this form of parasite as well as on cell culture derived trypomastigotes. The fluorescence method used here was very useful as it allowed for the simultaneous study of trypanocide activity and cytotoxicity by determining living or dead parasites within living or dead host cells. According to these results, the greatest trypanocide activity on cell culture-derived trypomastigotes was recorded...
Tipo: Journal article Palavras-chave: Nifurtimox; Nanoparticles; Amastigotes; Trypomastigotes; Trypanosoma cruzi.
Ano: 2002 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000100007
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