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	Provedor de dados BJPS (1) Autor Andreazza,Itamar Francisco (1) Galan,Vanderson (1) Martins,Sarah Moherdaui (1) Müller,Vinicius (1) Rosa,Maurício Ferreira da (1) Souza,Fabio Pinheiro de (1) Mais... Palavra-chave Biphasic Release (1) Cellulosic Polymers (1) Chronotherapy (1) Experimental Design (1) Pellets (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2018 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Development and evaluation of multiparticulate biphasic system for the treatment of circadian diseases BJPS Martins,Sarah Moherdaui; Müller,Vinicius; Galan,Vanderson; Souza,Fabio Pinheiro de; Andreazza,Itamar Francisco; Rosa,Maurício Ferreira da. Multiparticulate systems have biopharmaceutical advantages when compared to the monolithic systems, once they allow different patterns of drug release and can be used in different treatments. The aim of the present work was to develop a biphasic controlled release delivery system, using propranolol hydrochloride (PROP) that can be used for the treatment of circadian diseases. This system was obtained by the combination of cellulosic polymers hydroxypropyl methylcellulose (HPMC) and ethylcellulose (EC) in a 2² factorial experimental design, which allowed the optimization of the development stage. The pellets produced and used in biphasic formulations were evaluated for physical and chemical characteristics and presented acceptable results. The immediate... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronotherapy; Biphasic Release; Pellets; Cellulosic Polymers; Experimental Design. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400607 Registros recuperados: 1 Primeira ... 1 ... Última

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