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Erythrocyte phosphoglucomutase activity of bipolar I patients currently using lithium or carbamazepine BJMBR
Montero-Lomelí,M.; Galvão,D.; Morais,B.B.; Nardi,A.E..
Lithium has been used for the last five decades to treat bipolar disorder, but the molecular basis of its therapeutic effect is unknown. Phosphoglucomutase is a key enzyme in the metabolism of glycogen. In yeast, rabbit and human HEK293 cells, it is inhibited by lithium in the therapeutic concentration range. We measured the phosphoglucomutase activity in erythrocytes and the inhibitor constant for lithium in a population of healthy subjects and compared them to those of bipolar patients treated with lithium or carbamazepine. The specific activity of phosphoglucomutase measured in vitro in erythrocytes from control subjects presented a normal distribution, with the difference between the lowest and the highest activity being approximately 2-fold (0.53-1.10...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Phosphoglucomutase; Lithium; Carbamazepine; Bipolar disorder.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000100003
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