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	Provedor de dados Nature Precedings (1) Autor Germain J. Fernando (1) Jie Zhong (1) Marion E. G. Brunck (1) Xiao Song Liu (1) Palavra-chave Cancer (1) Immunology (1) Tipo do documento Manuscript (1) Ano 2009 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Cervical Cancer-Associated Human Papillomavirus 16 E7 Oncoprotein Inhibits Induction of Anti-Cancer Immunity by a CD4+ T Cell Dependent Mechanism Nature Precedings Marion E. G. Brunck; Xiao Song Liu; Jie Zhong; Germain J. Fernando. Attempts to develop therapeutic vaccines against cervical cancer have been proven difficult. One of the major causes of the failure is due to the use of the wrong mouse models based on transplantable tumours in testing the efficacy of vaccines. Now that a transgenic epithelial mouse model has been developed to closely mimic cervical cancer, the mechanisms needed to eliminate this type of cancer could be studied. The E7 oncoprotein of Human Papillomavirus (HPV) is the most expressed HPV protein in cervical cancers and its continuous production is essential to maintain the cancerous state and therefore the obvious target in the development of vaccines. Skin grafts expressing the HPV 16 E7 protein (E7 autografts) are not spontaneously rejected from an MHC... Tipo: Manuscript Palavras-chave: Cancer; Immunology. Ano: 2009 URL: http://precedings.nature.com/documents/3405/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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