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Construction of an engineered alpha 1-antitrypsin with inhibitory activity based on theoretical studies Electron. J. Biotechnol.
Sangachini,Elham Dasi; Hasannia,Sadegh; Taghdir,Majid; Pirooznia,Nazanin; Ghadicholaei,Kamran Khalili.
Background: The elastase inhibitor α-1-antitrypsin (AAT), is a member of the serpin superfamily of protease inhibitors. AAT has a characteristic secondary structure of three-β-sheets, nine-α-helices and a reactive central loop (RCL). This protein inhibits target proteases by forming a stable complex in which the cleaved RCL is inserted into β-sheet-A of the serpin, leading to a conformational change in the AAT protein. Spontaneous polymerization and instability of AAT are challenges with regard to producing drugs against AAT-deficient diseases. Therefore, the purpose of many investigations currently is to produce drugs with lower degrees of polymerization and higher stabilities. In order to investigate the effect of the...
Tipo: Journal article Palavras-chave: Alpha1-antitrypsin; Molecular dynamic simulation; Pichia pastoris.
Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582012000200008
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