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	Provedor de dados BJPS (2) Autor Ghaffari,Solmaz (2) Alihosseini,Faezeh (1) Attar,Hossein (1) Dabirsiaghi,Ali Reza (1) Goudarzi,Masoumeh (1) Haghighat,Setareh (1) Hajmalek,Monireh (1) Mazlaghan,Mehrnoosh Ghanbari (1) Mais... Palavra-chave Antibacterial efficacy (1) Cryoprotectant (1) Freeze-drying (1) High Performance Thin Layer Chromatography/method/validation (1) Particle size (1) Solid lipid nanoparticles (1) Stability (1) Sunitinib malate/E-Z isomer. (1) Sunitinib malate/quantitative analysis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2016 (1) 2015 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Freeze-drying of ampicillin solid lipid nanoparticles using mannitol as cryoprotectant BJPS Alihosseini,Faezeh; Ghaffari,Solmaz; Dabirsiaghi,Ali Reza; Haghighat,Setareh. abstract Solid lipid nanoparticles (SLNs) are interesting colloidal drug-delivery systems, since they have all the advantages of the lipid and polymeric nanoparticles. Freeze-drying is a widely used process for improving the stability of SLNs. Cryoprotectants have been used to decrease SLN aggregations during freeze-drying. In this study Ampicillin was chosen to be loaded in a cholesterol carrier with nano size range. To support the stability of SLNs, freeze-drying was done using mannitol. Particle size, drug release profile and antibacterial effects were studied after freeze-drying in comparison with primary SLNs. Preparations with 5% mannitol showed the least particle size enlargement. The average particle size was 150 and 187 nm before and after... Tipo: Info:eu-repo/semantics/article Palavras-chave: Solid lipid nanoparticles; Stability; Cryoprotectant; Freeze-drying; Antibacterial efficacy; Particle size. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400797 Development and validation of a HPTLC method for analysis of Sunitinib malate BJPS Hajmalek,Monireh; Goudarzi,Masoumeh; Ghaffari,Solmaz; Attar,Hossein; Mazlaghan,Mehrnoosh Ghanbari. ABSTRACT A simple high performance thin layer chromatography (HPTLC) has been developed and validated for determination of sunitinib malate and possible impurities. The samples were applied in forms of bands on an aluminum TLC plate pre-coated with silica gel and were separated using dichloromethane: methanol: toluene: ammonia solution as the mobile phase. Sunitinib malate was thoroughly separated from impurities including E-isomer, sunitinib N-oxide and impurity B with a retention factor (RF) of 0.35±0.02. Quantitative analysis of sunitinib was carried out using a mobile phase consisting of dichloromethane:methanol:ammonia solution, RF value was 0.53±0.02 for Z isomer. Detection was performed densitometrically in absorbance mode at 430 nm. This method was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sunitinib malate/quantitative analysis; High Performance Thin Layer Chromatography/method/validation; Sunitinib malate/E-Z isomer.. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400595 Registros recuperados: 2 Primeira ... 1 ... Última

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