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Behavioral and physiological methods for early quantitative assessment of spinal cord injury and prognosis in rats BJMBR
Giglio,C.A.; Defino,H.L.A.; da-Silva,C.A.; de-Souza,A.S.; Del Bel,E.A..
Methods for reliable evaluation of spinal cord (SC) injury in rats at short periods (2 and 24 h) after lesion were tested to characterize the mechanisms implicated in primary SC damage. We measured the physiological changes occurring after several procedures for producing SC injury, with particular emphasis on sensorimotor functions. Segmental and suprasegmental reflexes were tested in 39 male Wistar rats weighing 250-300 g divided into three control groups that were subjected to a) anesthesia, b) dissection of soft prevertebral tissue, and c) laminectomy of the vertebral segments between T10 and L1. In the lesion group the SC was completely transected, hemisected or subjected to vertebral compression. All animals were evaluated 2 and 24 h after the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Trauma; Spinal cord injury; Experimental models; Sensorial test; Motor performance test.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001200013
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