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Nuclear calcium signaling: a cell within a cell BJMBR
Rodrigues,M.A.; Gomes,D.A.; Nathanson,M.H.; Leite,M.F..
Calcium (Ca2+) is a versatile second messenger that regulates a wide range of cellular functions. Although it is not established how a single second messenger coordinates diverse effects within a cell, there is increasing evidence that the spatial patterns of Ca2+ signals may determine their specificity. Ca2+ signaling patterns can vary in different regions of the cell and Ca2+ signals in nuclear and cytoplasmic compartments have been reported to occur independently. No general paradigm has been established yet to explain whether, how, or when Ca2+ signals are initiated within the nucleus or their function. Here we highlight that receptor tyrosine kinases rapidly translocate to the nucleus. Ca2+ signals that are induced by growth factors result from...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Calcium; Proliferation; Receptor tyrosine kinases; Nucleus.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100004
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Nitrergic modulation of vasopressin, oxytocin and atrial natriuretic peptide secretion in response to sodium intake and hypertonic blood volume expansion BJMBR
Ventura,R.R.; Gomes,D.A.; Reis,W.L.; Elias,L.L.K.; Castro,M.; Valença,M.M.; Carnio,E.C.; Rettori,V.; McCann,S.M.; Antunes-Rodrigues,J..
The central nervous system plays an important role in the control of renal sodium excretion. We present here a brief review of physiologic regulation of hydromineral balance and discuss recent results from our laboratory that focus on the participation of nitrergic, vasopressinergic, and oxytocinergic systems in the regulation of water and sodium excretion under different salt intake and hypertonic blood volume expansion (BVE) conditions. High sodium intake induced a significant increase in nitric oxide synthase (NOS) activity in the medial basal hypothalamus and neural lobe, while a low sodium diet decreased NOS activity in the neural lobe, suggesting that central NOS is involved in the control of sodium balance. An increase in plasma concentrations in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Vasopressin; Oxytocin; ANP; Nitric oxide; Blood volume expansion; Sodium diet.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000900011
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