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The APOB rs693 polymorphism impacts the lipid profile of Brazilian older adults BJMBR
Alves,E.S.; Henriques,A.D.; Tonet-Furioso,A.C.; Paula,R.S.; Gomes,L.O.; Moraes,C.F.; Nóbrega,O.T..
The apolipoprotein B (APOB) gene contains several polymorphic sites described as risk modifiers for cardiovascular events. The objective of this study was to verify the association of the classic APOB Xba I polymorphism (rs693) with atherosclerotic risk factors in a segment of the Brazilian elderly population considering their usual dietary intake. Clinical and biochemical characteristics as well as total caloric and fat intake data were determined from 644 elderly individuals. Polymorphism analysis was performed by conventional polymerase chain reaction followed by enzyme restriction. Statistical analyses compared measures and proportions according to different APOB genotypic combinations. Statistically significant association was found between Xba I...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Apolipoprotein B; Genetic polymorphism; Elderly; Hyperlipidemia; Diet.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000300608
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