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| Pavan,Maria Helena Postal; Pavin,Elizabeth João; Gonçales Jr,Fernando Lopes; Zantut-Wittmann,Denise Engelbrecht. |
| OBJECTIVE: The treatment of the chronic hepatitis C (HCV) with α-interferon is associated with thyroid dysfunction (TD). The aim of this study was to evaluate thyroid function outcome among patients with chronic HCV under treatment with conventional interferon (IFN) or peguilated interferon (PEG-IFN) in association with ribavirin. PATIENTS AND METHODS: We studied 293 patients with chronic HCV, submitted to drug therapy for 24 or 48 weeks. Initially, we evaluated FT4, TSH, TPOAb, TgAb, and continued to monitor FT4 and TSH every three months during therapy and six months thereafter. RESULTS: At baseline, TD prevalence was 6.82% (n = 20); 6.14% hypothyroidism; 0.68% hyperthyroidism. TPOAb was present in 5.46% of euthyroid patients. Out of 273 euthyroid... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hypothyroidism hepatitis C; Chronic interferon-α. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500006 |
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| Vigani,Aline Gonzalez; Gonçales,Eduardo Sellan; Pavan,Maria Helena Postal; Genari,Flavia; Tozzo,Raquel; Lazarini,Maria Silvia Kroll; Fais,Viviane; Feltrin,Adriana; Gonçales,Neiva Sellan; Gonçales Jr,Fernando Lopes. |
| BACKGROUND: Pegylated interferon (Peg-IFN) and standard interferon (IFN) play a significant role in the treatment of hepatitis C virus (HCV) infection. Biosimilar standard IFN is widely available in Brazil for the treatment of HCV infection genotypes 2 or 3, but its efficacy compared to Peg-IFN is unknown. OBJECTIVE: To compare the sustained virological response (SVR) rates following treatment with biosimilar standard IFN plus ribavirin (RBV) versus Peg-IFN plus RBV in patients with HCV genotypes 2 or 3 infection. METHODS: A retrospective cohort study was conducted in patients with HCV genotypes 2 or 3 infection treated with biosimilar standard IFN plus RBV or with Peg-IFN plus RBV. SVR rates of the two treatments were compared. RESULTS: From January 2005... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Interferons; Hepatitis C; Treatment outcome. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300003 |
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