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| Elies, G.; Duval, H.; Groigno, L.; Wolff, J.; Boeuf, Gilles; Boujard, D.. |
| The IGFs, their receptors and their binding proteins constitute a family of cellular modulators that play essential functions in the regulation of growth and development. In our study, we have carried out the molecular characterization of the IGF-I and its receptor (IGF-1R) from the turbot (Psetta maxima), a teleost flatfish. By RT-PCR, we have cloned an IGF-I cDNA. The deduced peptide shows 70-96 % identity with the other vertebrate IGF-I sequences previously described. We have also cloned a cDNA encoding the IGF type 1 receptor precursor from an embryos cDNA library. The deduced IGF-1R primary sequence contains all the topological features characteristic of the IGF-1R. Indeed, the turbot receptor is highly conserved compared to its mammalian... |
| Tipo: Text |
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| Ano: 1998 |
URL: https://archimer.ifremer.fr/doc/00480/59132/61760.pdf |
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