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| Sampaio,I.C.; Medeiros,P.H.Q.S.; Rodrigues,F.A.P.; Cavalcante,P.A.; Ribeiro,S.A.; Oliveira,J.S.; Prata,M.M.G.; Costa,D.V.S.; Fonseca,S.G.C.; Guedes,M.M.; Soares,A.M.; Brito,G.A.C.; Havt,A.; Moore,S.R.; Lima,A.A.M.. |
| Undernutrition represents a major public health challenge for middle- and low-income countries. This study aimed to evaluate whether a multideficient Northeast Brazil regional basic diet (RBD) induces acute morphological and functional changes in the ileum of mice. Swiss mice (∼25 g) were allocated into two groups: i) control mice were fed a standard diet and II) undernourished mice were fed the RBD. After 7 days, mice were killed and the ileum collected for evaluation of electrophysiological parameters (Ussing chambers), transcription (RT-qPCR) and protein expression (western blotting) of intestinal transporters and tight junctions. Body weight gain was significantly decreased in the undernourished group, which also showed decreased crypt depth but no... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Undernutrition; Ion transport; Intestinal absorption. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001000607 |
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