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| CHEN,SONGLIN; YANG,LEI; PAN,AIPING; DUAN,SILIANG; LI,MINGFEN; LI,PING; HUANG,JINGJING; GAO,XINGXIN; HUANG,XIAOQI; LIN,YINGHUI. |
| Abstract: The aim of this study was to investigate the inhibitory effect of regulation of miR-122-MAP3K2 signal pathway on the hepatitis B cells. We detected the content of MAP3K2 from patients with HBV blood serum samples and analyzed the correlation between content of MAP3K2 and copies of HBV-DNA. Wound healing and Transwell assays were used to detect the function of cells from control group (wild type) and observer group (overexpresses miR-122). Secretion levels of HBsAg and MAP3K2 in the supernatant and level of MAP3K2 in cells were detected by ELISA and western blot, respectively. The results showed that there was a positive correlation between the copies of HBV-DNA and MAP3K2 in serum. In the assays involving detection of the number of HBV-DNA... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis B cells; MiR-122; Inhibit; Signaling pathway. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300703 |
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