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	Provedor de dados Braz. J. Genet. (1) Autor Harb-Gama,Angelito (1) Lopes,Ademar A. (1) Nagai,Maria A. (1) Yamamoto,Lidia (1) Palavra-chave Chromosome 17 (1) Colorectal tumors (1) Heterozygosity (1) TP53 mutations (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 1996 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última TP53 mutations and loss of heterozygosity of chromosome 17 in colorectal tumors Braz. J. Genet. Yamamoto,Lidia; Lopes,Ademar A.; Harb-Gama,Angelito; Nagai,Maria A.. The incidence of TP53 point mutations and loss of heterozygosity (LOH) of chromosome 17 in colorectal tumors was determined in a group of Brazilian patients. We screened DNA samples from tumors and distal normal mucosa of 39 patients with colorectal cancer, for TP53 mutations by PCR-SSCP (single-strand conformation polymorphism) analysis. Chromosome 17 LOH was investigated using six PCR-based polymorphic markers and one VNTR probe. TP53 mutations were demonstrated in 15/39 of the cases. Mutations were distributed among all exons examined (five to eight), the majority of them being G/C to A/T transitions. LOH of chromosome 17p and 17q was detected in 70 and 46% of the tumors, respectively. There was a significant association between TP53 mutations and LOH... Tipo: Info:eu-repo/semantics/article Palavras-chave: TP53 mutations; Heterozygosity; Chromosome 17; Colorectal tumors. Ano: 1996 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551996000400022 Registros recuperados: 1 Primeira ... 1 ... Última

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