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| Israr,Fozia; Mahmood,Zafar Alam; Hassan,Fouzia; Hasan,Syed Muhammad Farid; Jabeen,Sabahat; Naz,Shazia; Bashir,Lubna. |
| Cefuroxime axetil immediate release tablets were formulated by direct compression method with different percentages of sodium lauryl sulphate (SLS) such as 0.5, 1.0, 1.5 and also without SLS. Resulting batches of tablets were evaluated by both pharmacopeial and non-pharmacopeial methods to ascertain the physico-mechanical properties. Dissolution test were carried out in different medium like 0.07 M HCl, distilled water, 0.1M HCl of pH 1.2 and phosphate buffers at pH 4.5 and 6.8 to observe the drug release against the respective concentration of SLS used. Later, test formulations were compared by f1(dissimilarity) and f2(similarity) factors using a reference brand of cefuroxime axetil. Significant differences (p<0.05) in dissolution rate were recorded... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cefuroxime axetil/immediate release tablets/physico-mechanical properties; Direct compression; Sodium lauryl sulphate. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400943 |
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