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| Hashiguchi-Kato, Rie; Thi, Pham Ngoc; Ohmori, Takashi; Tamahara, Satoshi; Katayama, Shinsuke; Shimada, Terumasa; Matsuki, Naoaki; Ono, Kenichiro. |
| Stimulatory factors for interleukin 12 (IL-12) production associated with Babesia microti and Babesia rodhaini infected erythrocytes were examined using an in vitro assay system established, since a remarkable increase of serum IL-12 concentration and differentiation of helper T cell (Th cell) into helper T cell type 1 (Th1 cell) was observed in early phase of infection with Babesia spp. in mice. To investigate direct stimulating activity of infected erythrocytes for IL-12 production, intact splenic macrophages were co-cultured with them and examined the expression of IL-12 mRNA by reverse transcription-polymerase chain reaction (RT-PCR). Both B. microti and B. rodhaini infected erythrocytes elicited IL-12 mRNA expression in co-cultured macrophages. Since... |
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Palavras-chave: Babesi microti and Babesia rodhaini infected erythrocyte; IL-12 Production; Mice; Splenic Macrophage; Stimulatory factor. |
| Ano: 2005 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/151 |
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