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Relationship between viral load and behavioral measures of adherence to antiretroviral therapy in children living with human immunodeficiency virus in Latin America BJID
Duarte,Horacio A.; Harris,Donald Robert; Tassiopoulos,Katherine; Leister,Erin; Negrini,Silvia Fabiana Biason de Moura; Ferreira,Flávia Faleiro; Cruz,Maria Letícia Santos; Pinto,Jorge; Allison,Susannah; Hazra,Rohan.
Few studies have examined antiretroviral therapy adherence in Latin American children. Standardized behavioral measures were applied to a large cohort of human immunodeficiency virus-infected children in Brazil, Mexico, and Peru to assess adherence to prescribed antiretroviral therapy doses during the three days prior to study visits, assess timing of last missed dose, and evaluate the ability of the adherence measures to predict viral suppression. Time trends in adherence were modeled using a generalized estimating equations approach to account for possible correlations in outcomes measured repeatedly in the same participants. Associations of adherence with human immunodeficiency virus viral load were examined using linear regression. Mean enrollment age...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pediatric; ART; Adherence; Latin America.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300263
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Tuberculosis in HIV-infected infants, children, and adolescents in Latin America BJID
Krauss,Margot R.; Harris,D. Robert; Abreu,Thalita; Ferreira,Fabiana G.; Ruz,Noris Pavia; Worrell,Carol; Hazra,Rohan.
Objective:To evaluate the occurrence, clinical presentations and diagnostic methods for tuberculosis in a cohort of HIV-infected infants, children and adolescents from Latin America.Methods:A retrospective analysis of children with tuberculosis and HIV was performed within a prospective observational cohort study conducted at multiple clinical sites in Latin America.Results:Of 1114 HIV-infected infants, children, and adolescents followed from 2002 to 2011, 69 that could be classified as having confirmed or presumed tuberculosis were included in this case series; 52.2% (95% CI: 39.8-64.4%) had laboratory-confirmed tuberculosis, 15.9% (95% CI: 8.2-26.7%) had clinically confirmed disease and 31.9% (95% CI: 21.2-44.2%) had presumed tuberculosis. Sixty-six were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tuberculosis HIV; Children; Latin America.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100023
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