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The 9-O-acetyl GD3 gangliosides are expressed by migrating chains of subventricular zone neurons in vitro BJMBR
Miyakoshi,L.M.; Mendez-Otero,R.; Hedin-Pereira,C..
Neurons from the anterior subventricular zone (SVZ) of the cerebral cortex migrate tangentially to become interneurons in the olfactory bulb during development and in adult rodents. This migration was defined as neuronophilic, independent of a radial glial substrate. The cortical SVZ and the rostral migratory stream to the olfactory bulb were shown to be rich in 9-O-acetyl GD3 gangliosides (9-O-acGD3), which have been previously shown to be implicated in gliophilic migration in the rodent cerebral cortex and cerebellum. In the present study, we performed SVZ explant cultures using rats during their first postnatal week to analyze the expression of these gangliosides in chain migration of neuronal precursors. We characterized migrating chains of these...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Subventricular zone; Migration; 9-O-acetylated gangliosides; Rostral migratory stream.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000500016
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Cell migration in the postnatal subventricular zone BJMBR
Menezes,J.R.L.; Marins,M.; Alves,J.A.J.; Fróes,M.M.; Hedin-Pereira,C..
New neurons are constantly added to the olfactory bulb of rodents from birth to adulthood. This accretion is not only dependent on sustained neurogenesis, but also on the migration of neuroblasts and immature neurons from the cortical and striatal subventricular zone (SVZ) to the olfactory bulb. Migration along this long tangential pathway, known as the rostral migratory stream (RMS), is in many ways opposite to the classical radial migration of immature neurons: it is faster, spans a longer distance, does not require radial glial guidance, and is not limited to postmitotic neurons. In recent years many molecules have been found to be expressed specifically in this pathway and to directly affect this migration. Soluble factors with inhibitory, attractive...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Postnatal neurogenesis; Chain migration; Rostral migratory stream; Astrocytes; Gap junctions; Radial glia.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001200002
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