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| Hughes, Kristelle; Ho, Raimana; Greff, Stéphane; Filaire, Edith; Ranouille, Edwige; Chazaud, Claire; Herbette, Gaëtan; Butaud, Jean-françois; Berthon, Jean-yves; Raharivelomanana, Phila. |
| Hair loss is becoming increasingly prevalent as dietary and living habits change. The search for natural products to limit hair loss has led to tapping into traditional cosmetic knowledge. We studied three plants of the Polynesian cosmetopoeia, Bidens pilosa, Calophyllum inophyllum and Fagraea berteroana, to determine their ability to promote hair growth. Their chemical content was characterized by liquid chromatography coupled to mass spectrometry (LC-MS). Their proliferative activity on dermal papilla cells (DPCs) was assessed via MTT assay and molecular targets were evaluated by RT-qPCR analysis of seven factors involved in the modulation of the hair cycle, CCND1, LEF1, DKK1, WNT5A PPARD, TGFΒ1, PPARD and RSPO2. Our results show that our extracts... |
| Tipo: Text |
Palavras-chave: Polynesian plants; Ethnobotany; Cosmetopoeia; Dermal papilla; Hair growth; Wnt. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00652/76409/77453.pdf |
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| Cassien, Mathieu; Mercier, Anne; Thétiot-laurent, Sophie; Culcasi, Marcel; Ricquebourg, Emilie; Asteian, Alice; Herbette, Gaëtan; Bianchini, Jean-pierre; Raharivelomanana, Phila; Pietri, Sylvia. |
| Tamanu oil from Calophyllum inophyllum L. has long been used in traditional medicine. Ethanol extraction was found the best strategy for recovering bioactive compounds from the resin part of Tamanu oil, yielding two neutral and acidic resins fractions with high phenolics, flavonoids and pyranocoumarins concentrations. A further cascade of LPLC/HPLC separations of neutral and acidic resin fractions allowed identifying fifteen metabolites, and among them, calanolide D and 12-oxocalanolide A (both in neutral fraction) were first identified from a natural source. All these extracts, subfractions and isolated metabolites demonstrated increased free radical scavenging, antioxidant, anti-inflammatory, antimicrobial and antimycobacterial activity compared to... |
| Tipo: Text |
Palavras-chave: Calophyllum inophyllum L; Tamanu oil; Ethanol-soluble resin extracts; Lipophilic antioxidants; Phenolics; Pyranocoumarins; Antimicrobial; Anti-inflammatory; UV protection; EPR spin trapping. |
| Ano: 2021 |
URL: https://archimer.ifremer.fr/doc/00677/78918/81283.pdf |
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