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Close inbreeding and low genetic diversity in Inner Asian human populations despite geographical exogamy ArchiMer
Marchi, Nina; Mennecier, Philippe; Georges, Myriam; Lafosse, Sophie; Hegay, Tatyana; Dorzhu, Choduraa; Chichlo, Boris; Segurel, Laure; Heyer, Evelyne.
When closely related individuals mate, they produce inbred offspring, which often have lower fitness than outbred ones. Geographical exogamy, by favouring matings between distant individuals, is thought to be an inbreeding avoidance mechanism; however, no data has clearly tested this prediction. Here, we took advantage of the diversity of matrimonial systems in humans to explore the impact of geographical exogamy on genetic diversity and inbreeding. We collected ethno-demographic data for 1,344 individuals in 16 populations from two Inner Asian cultural groups with contrasting dispersal behaviours (Turko-Mongols and Indo-Iranians) and genotyped genome-wide single nucleotide polymorphisms in 503 individuals. We estimated the population exogamy rate and...
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Ano: 2018 URL: https://archimer.ifremer.fr/doc/00477/58916/61480.pdf
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