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| Motoko Nishimura; Hideya Sato; Hitoshi Okazaki; Masahiro Satake; Kenji Tadokoro. |
| Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor, has pleiotropic effects in immunoregulation and inflammation. It is capable of inhibiting synthesis of pro-inflammatory cytokines like interferon γ (IFNγ), IL-2, IL-3, tumor necrosis factor α(TNFα) and granulocyte macrophage colony stimulating factor (GM-CSF) made by cells such as macrophages and T helper Type 1 cells. We observed that normal human serum, derived from a healthy individual but containing large amounts of IL-10 (arbitrarily designated as "IL-10 serum"), inhibited cytotoxic activity and interfered with granzyme B release from alloreactive cytotoxic T cell (CTL) clones _in vitro_, but did not affect perforin... |
| Tipo: Manuscript |
Palavras-chave: Immunology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1464/version/1 |
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| Motoko Nishimura; Hideya Sato; Hitoshi Okazaki; Masahiro Satake; Kenji Tadokoro. |
| Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor, has pleiotropic effects in immunoregulation and inflammation. It is capable of inhibiting synthesis of pro-inflammatory cytokines like interferon [gamma] (IFN[gamma]), IL-2, IL-3, tumor necrosis factor [alpha] (TNF[alpha]) and granulocyte macrophage colony stimulating factor (GM-CSF) made by cells such as macrophages and T helper Type 1 cells. We observed that normal human serum, derived from a healthy individual but containing large amounts of IL-10 (arbitrarily designated as "IL-10 serum"), inhibited cytotoxic activity and interfered with granzyme B release from alloreactive cytotoxic T cell clones in vitro, but did not affect perforin release. The addition of... |
| Tipo: Manuscript |
Palavras-chave: Immunology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1390/version/1 |
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