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	Provedor de dados BJMBR (2) Autor Hoffmann,P. (2) Bernardes-Genisson,V. (1) Bringaud,F. (1) Labidalle,S. (1) Petit,C. (1) Périé,J. (1) Souchard,J.-P. (1) Soulère,L. (1) Mais... Palavra-chave Nitric oxide (2) Peroxynitrite (2) Adenosine (1) Antioxidant (1) S-nitrosothiol (1) S-nitrosothiols (thionitrites) (1) Thionitrite (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 1999 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Novel donors of nitric oxide derived of S-nitrosocysteine possessing antioxidant activities BJMBR Petit,C.; Bernardes-Genisson,V.; Hoffmann,P.; Souchard,J.-P.; Labidalle,S.. Novel S-nitrosothiols possessing a phenolic function were investigated as nitric oxide (NO) donors. A study of NO release from these derivatives was carried out by electron spin resonance (ESR). All compounds gave rise to a characteristic three-line ESR signal in the presence of the complex [Fe(II)(MGD)2], revealing the formation of the complex [Fe(II)(MGD)2(NO)]. Furthermore, tests based on cytochrome c reduction were performed in order to study the ability of each phenolic disulfide, the final organic decomposition product of S-nitrosothiols, to trap superoxide radical anion (O2-). This study revealed a high reactivity of 1b and 3b towards O2-. For these two compounds, the respective inhibitory concentration (IC) 50 values were 92 µM and 43 µM. Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; S-nitrosothiols (thionitrites); Antioxidant; Peroxynitrite. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100011 Uptake of NO-releasing drugs by the P2 nucleoside transporter in trypanosomes BJMBR Soulère,L.; Hoffmann,P.; Bringaud,F.; Périé,J.. Nitric oxide (NO·) has been identified as a principal regulatory molecule of the immune system and the major cytotoxic mediator of activated immune cells. NO· can also react rapidly with a variety of biological species, particularly with the superoxide radical anion O2·- at almost diffusion-limited rates to form peroxynitrite anion (ONOO-). ONOO- and its proton-catalyzed decomposition products are capable of oxidizing a great diversity of biomolecules and can act as a source of toxic hydroxyl radicals. As a consequence, a strategy for the development of molecules with potential trypanocidal activities could be developed to increase the concentration of nitric oxide in the parasites through NO·-releasing compounds. In this way, the rate of formation of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Peroxynitrite; Thionitrite; S-nitrosothiol; Adenosine. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100016 Registros recuperados: 2 Primeira ... 1 ... Última

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