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| Hughes, Kristelle; Ho, Raimana; Greff, Stéphane; Filaire, Edith; Ranouille, Edwige; Chazaud, Claire; Herbette, Gaëtan; Butaud, Jean-françois; Berthon, Jean-yves; Raharivelomanana, Phila. |
| Hair loss is becoming increasingly prevalent as dietary and living habits change. The search for natural products to limit hair loss has led to tapping into traditional cosmetic knowledge. We studied three plants of the Polynesian cosmetopoeia, Bidens pilosa, Calophyllum inophyllum and Fagraea berteroana, to determine their ability to promote hair growth. Their chemical content was characterized by liquid chromatography coupled to mass spectrometry (LC-MS). Their proliferative activity on dermal papilla cells (DPCs) was assessed via MTT assay and molecular targets were evaluated by RT-qPCR analysis of seven factors involved in the modulation of the hair cycle, CCND1, LEF1, DKK1, WNT5A PPARD, TGFΒ1, PPARD and RSPO2. Our results show that our extracts... |
| Tipo: Text |
Palavras-chave: Polynesian plants; Ethnobotany; Cosmetopoeia; Dermal papilla; Hair growth; Wnt. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00652/76409/77453.pdf |
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| Hughes, Kristelle; Ho, Raimana; Chazaud, Claire; Hermitte, Stéphanie; Greff, Stéphane; Butaud, Jean-françois; Filaire, Edith; Ranouille, Edwige; Berthon, Jean-yves; Raharivelomanana, Phila. |
| Fagraea berteroana is a tree used in traditional medicine in various islands of the South Pacific. Here, we studied its hair growth-inducing properties as suggested by one of its Marquesan ethno-uses in haircare. The ethyl acetate extract of the fruits of F. berteroana (FEAE) and four resulting fractions (FEAE-F0, FEAE-F1, FEAE-F2, and FEAE-F3) were tested on hair follicle dermal papilla cells to determine their cell proliferative activity. Furthermore, RT-qPCR analysis enabled gene modulation analysis, while immunostaining of the β-catenin protein was used to follow protein regulation. We found that the plant extracts induced a controlled, dose-dependent cell proliferation. FEAE-F0 simultaneously down-regulated Bone Morphogenetic Protein 2 (BMP2) mRNA... |
| Tipo: Text |
Palavras-chave: Fagraea berteroana; Hair growth; Ethnocosmetology; Marquesas islands; Gentianaceae. |
| Ano: 2021 |
URL: https://archimer.ifremer.fr/doc/00678/79021/81426.pdf |
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