Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados Nature Precedings (3) Autor Amineni Umamaheswari (3) I Vani Priyadarshini (3) Kanipakam Hema (1) Pallapotu Navya (1) Varala Sravani (1) Palavra-chave Bioinformatics (3) Cancer (1) Plant Biology (1) Tipo do documento Presentation (2) Poster (1) Ano 2011 (3) País United Kingdom (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Identification of small molecule inhibitor of cyclophilin-A using high throughput virtual screening and molecular docking Studies Nature Precedings Pallapotu Navya; I Vani Priyadarshini; Amineni Umamaheswari. The inhibitors of cyclophilin A (CyPA) have drawn a great deal of attention due to their promising potential as small-molecule therapeutics for the treatment of cardiovascular diseases. This ultimately prompts to explore structural geometries of these inhibitors to obtain insights on next generation CyPA inhibitors through rational drug designing. Herein, 2D similarity search for the seven CyPA inhibitors was performed using Ligand.Info database. Small subsets of 2800 molecules from one million compounds were predicted to have activity against cardiovascular drug target CyPA. The binding strength of 2800 ligands with CyPA was assessed through molecular docking analysis using Schrödinger software 2011. The CyPA co-crystal structure and ligand... Tipo: Presentation Palavras-chave: Cancer; Bioinformatics. Ano: 2011 URL: http://precedings.nature.com/documents/6529/version/1 Mizoribin as a inhibitor for leukocyte immunoglobulin receptor sub family A member3 Nature Precedings Varala Sravani; I Vani Priyadarshini; Amineni Umamaheswari. The Leukocyte Immunoglobulin-like Receptors (LILRs) are a family of receptors that was broadly expressed on all leukocytes and have the ability to regulate their function. The increased levels of human LILRA3 in rheumatoid arthritis patients leads to stroke. In quest of designing novel inhibitors against LILRA3 an accurate homology model for the protein was based on crystal structures of 1GOX and 3P2T using Modeller 9V9. The use of multiple templates for structure prediction led us to propose a structure comprising all 439 amino acids of human LILRA3 for the first time. The best model was selected based on GA341 and DOPE score and further assessed through ProSA and PROCHECK. The validated structure was subjected to CASTp analysis ligand binding site... Tipo: Presentation Palavras-chave: Bioinformatics; Plant Biology. Ano: 2011 URL: http://precedings.nature.com/documents/6532/version/1 Identification of new leads for human IGFBP-2: a therapeutic target for cardiovascular diseases Nature Precedings Kanipakam Hema; I Vani Priyadarshini; Amineni Umamaheswari. IGFBP-2, the largest member of insulin-like growth factor binding proteins family, is under-expressed in hazardous cardiovascular diseases like obesity and type II diabetes mellitus, which upon aging leads to heart stroke. Therefore, IGFBP-2 has been proposed as a possible target for the development of novel leads for cardiovascular disease therapy. High-throughput virtual screening, one of the most common methods used to identify lead compounds was implemented here to identify potential IGFBP-2 activators. The NMR (nuclear magnetic resonance) structure of human IGFBP-2 was retrieved from the protein data bank. A 2D similarity search was performed for known IGFBP-2 activator TPA to acquire 383 structural analogs. The 3D structural conversion and multiple... Tipo: Poster Palavras-chave: Bioinformatics. Ano: 2011 URL: http://precedings.nature.com/documents/6570/version/1 Registros recuperados: 3 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco