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| UBAID,MUHAMMAD; ILYAS,SADAF; MIR,SADULLAH; KHAN,ABIDA K.; RASHID,REHANA; KHAN,MUHAMMAD Z.U.; KANWAL,ZAINAB G.; NAWAZ,AHMAD; SHAH,AMNA; MURTAZA,GHULAM. |
| ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effect of independent variables i.e. coconut oil (X1), pistachio oil (X2) and sodium lauryl sulphate (X3) at various dependent variables i.e. flux (Y1), lag time (Y2), diffusion coefficient (Y3), permeability coefficient (Y4), and input rate (Y5) of clotrimazole gel formulations. Ex vivo skin permeation study was performed through rat skin by using modified Franz... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Central composite design; Clotrimazole; Permeability enhancer; Topical gel. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602303 |
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