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	Provedor de dados BJPS (2) Autor Ibrahim,Mohamed Abbas (2) Mahrous,Gamal Mohamed (2) Auda,Sayed Hassan (1) Kassem,Mohamed Gabr (1) Palavra-chave Clopidogrel/orally disintegrating tablets (1) Dextromethorphan hydrobromide (1) Extrusion spheronization (1) Matrix pellets (1) Mix torque rheometer (MTR) (1) Orally disintegrating tablets/evaluation (1) Orally disintegrating tablets/formulation (1) Superdisintegrants (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2016 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Formulation and evaluation of orally disintegrating clopidogrel tablets BJPS Mahrous,Gamal Mohamed; Kassem,Mohamed Gabr; Ibrahim,Mohamed Abbas; Auda,Sayed Hassan. ABSTRACT Recent advances in drug delivery systems have aimed to achieve better patient compliance. One of these advances is the formulation of orally disintegrating tablets (ODTs) that dissolve instantaneously, releasing drugs within a few seconds without the need of water. The main objective of this paper was to prepare and develop ODTs of clopidogrel. The ODTs were prepared by direct compression. The effect of three superdisintegrants, namely crospovidone, croscarmellose sodium, and sodium starch glycolate, using three different disintegration times on the dissolution rate was investigated. The prepared tablets were evaluated for hardness, friability, disintegration time and in vitro drug release. Furthermore, the interaction of clopidogrel with the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Clopidogrel/orally disintegrating tablets; Superdisintegrants; Orally disintegrating tablets/formulation; Orally disintegrating tablets/evaluation. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000200309 Effect of wet mass on dextromethorphan hydrobromide matrix pellets BJPS Ibrahim,Mohamed Abbas; Mahrous,Gamal Mohamed. Dextromethorphan hydrobromide (DM) sustained release matrix pellets containing 10% w/w drug were prepared by an extrusion/spheronization technique. The effect of mixing different concentrations of ethyl cellulose (EC), hydroxypropyl methylcellulpse (HPMC K10), and Carbopol 934 with Avicel PH101 on the rheological properties of pellet wet mass was evaluated using mixer torque rheometry (MTR). The prepared pellets were characterized for size, drug content, and in-vitro DM release rate. The results showed that increasing the concentration of the hydrophobic polymer (EC) with Avicel PH101 decreased wet mass consistency, represented by mass mean line torque. Lower binder ratio was required for optimum wet massing, while mixing with swellable polymers (HPMC and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Dextromethorphan hydrobromide; Matrix pellets; Extrusion spheronization; Mix torque rheometer (MTR). Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400604 Registros recuperados: 2 Primeira ... 1 ... Última

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