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| Giorgetti,Leandro; Issa,Michele Georges; Ferraz,Humberto Gomes. |
| The aim of this study was to evaluate the effect of dissolution medium, rotation speed and compaction pressure on the intrinsic dissolution rate (IDR) of the antihypertensive drug amlodipine besylate, using the rotating disk method. Accordingly, a fractional factorial design (33-1) was used, employing dissolution media (water, phosphate buffer pH 6.8 and HCl 0.1 M), rotation speed (50, 75 and 100 rpm), and compaction pressure (1000, 1500 and 2000 psi) as independent variables. The assays were randomized and statistically compared using the Statistica(r) 11 software program. Significance testing (ANOVA) indicated that the dissolution medium had a considerable impact on the IDR of amlodipine besylate. Analysis of the linear and quadratic components of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amlodipine besylate/intrinsic dissolution; Biopharmaceutical classification system; Drugs/experimental design; Antihypertensive drugs/Amlodipine besylate. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300513 |
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| Issa,Michele Georges; Souza,Natalia Vieira de; Duque,Marcelo Dutra; Ferraz,Humberto Gomes. |
| ABSTRACT The search for new pharmaceutical dosage forms and different drug delivery systems already used in therapeutics is a global trend, serving as an opportunity to expand the portfolio for the pharmaceutical industry. In this context, multiparticulate systems, such as pellets, granules, and minitablets, represent an attractive alternative, given the range of possibilities they provide. Among the methods used in the production of these systems, we highlight the process of extrusion-spheronization for pellet manufacture, wet granulation and hot-melt extrusion for the obtention of granules, and direct compression for minitablets. Although highly versatile, depending on the technology chosen, many processes and formulation variables can influence the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Multiparticulate systems/physical characterization; Pellets; Granules; Minitablets. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400403 |
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| Issa,Michele Georges; Pessole,Letícia; Takahashi,Andrea Ikeda; Andréo Filho,Newton; Ferraz,Humberto Gomes. |
| With the purpose of evaluating the behavior of different polymers employed as binders in small-diameter pellets for oral administration, we prepared formulations containing paracetamol and one of the following polymers: PVP, PEG 1500, hydroxypropylmethylcellulose and methylcellulose, and we evaluated their different binding properties. The pellets were obtained by the extrusion/spheronization process and were subsequently subjected to fluid bed drying. In order to assess drug delivery, the United States Pharmacopeia (USP) apparatus 3 (Bio-Dis) was employed, in conjunction with the method described by the same pharmacopeia for the dissolution of paracetamol tablets (apparatus 1). The pellets were also evaluated for granulometry, friability, true density and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Binders/evaluation; Pellets/dissolution profile; Pellets/physicochemical characteristics; Extrusion/spheronization process; Drug delivery/evaluation. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000300004 |
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| Graziola,Fabiana; Candido,Thalita Marcílio; Oliveira,Camila Areias de; Peres,Daniela D'Almeida; Issa,Michele Georges; Mota,Joana; Rosado,Catarina; Consiglieri,Vladi Olga; Kaneko,Telma Mary; Velasco,Maria Valéria Robles; Baby,André Rolim. |
| ABSTRACT Glutaraldehyde (GTA) has been extensively used as a gelatin crosslinking agent, however, new natural ones have been suggested as more biocompatible. Polyphenols are possible candidates and the flavonols, such as rutin (RUT), also exhibit potential synergism with sunscreens and antioxidant agents used in cosmetics. In this work, gelatin microspheres (M0) were obtained and crosslinked with GTA 10 mM (MG) or RUT 10 mM (MR), dissolved in acetone:NaOH 0,01M (70:30 v/v). MG exhibited crosslinking extent of 54.4%. Gelatin, M0, MG and MR did not elicit any signs of skin damage, regarding the formation of erythema, the barrier function disruption and negative interference in the stratum corneum hydration. Oily dispersions containing M0, MG or MR, isolated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Protection solar/tests; Gelatin/microspheres/safety testing; Glutaraldehyde/safety testing; Flavonoids/Rutin/use in cosmetics; Natural products/use in cosmetics.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400603 |
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