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	Provedor de dados Frontis (3) Autor Jacobs-Lorena, M. (3) Christophides, G.K. (2) James, A.A. (2) Olson, K.E. (2) Benedict, M.Q. (1) Gouagna, L.C. (1) Mais... Tipo do documento Conference proceedings (3) Ano 2005 (3) País Netherlands (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Evaluation of drive mechanisms (including transgenes and drivers) in different environmental conditions and genetic backgrounds Frontis James, A.A.; Benedict, M.Q.; Christophides, G.K.; Jacobs-Lorena, M.; Olson, K.E.. Three major objectives, develop viable gene drive mechanisms, identify the epidemiologically significant vectors of pathogens in specific transmission zones, and introgress effector genes into specific populations, must be met in order to move to the field laboratory advances in genetic control strategies Tipo: Conference proceedings Ano: 2005 URL: http://library.wur.nl/ojs/index.php/frontis/article/view/1193 Genetic approaches for malaria control Frontis Jacobs-Lorena, M.. The already unacceptable large burden of malaria continues to increase, indicating that the available means to fight the disease are insufficient. The genetic manipulation of the mosquito vectorial competence is a potential new promising weapon for the control of malaria. Considerable progress has been made in recent years towards this goal. It is now possible to introduce synthetic genes into the mosquito germ line, promoters have been identified that effectively drive gene expression in tissues and at times appropriate to target the parasite, and effector genes that impair parasite development in the mosquito have been identified. With these tools, proof-of-concept experiments have already demonstrated that it is possible to interfere genetically with... Tipo: Conference proceedings Ano: 2005 URL: http://library.wur.nl/ojs/index.php/frontis/article/view/1185 What are relevant assays for refractoriness? Frontis Christophides, G.K.; Gouagna, L.C.; Jacobs-Lorena, M.; James, A.A.; Olson, K.E.. The engineering and testing of genes that result in refractory phenotypes are important components of the continuing effort towards the use of population replacement strategies for vector control. Both ‘endogenous’ and ‘synthetic’ refractory phenotypes are being considered. Additional research is required to determine the prevalence of such phenotypes in the various vector–pathogen combinations, and the threshold levels of activity of genes conferring transmission blocking, as well as to develop efficient methods for the evaluation of their entire spectrum of biological effects Tipo: Conference proceedings Ano: 2005 URL: http://library.wur.nl/ojs/index.php/frontis/article/view/1195 Registros recuperados: 3 Primeira ... 1 ... Última

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