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| Jalili,C; Salahshoor,M. R; Khademi,F; Jalili,P; Roshankhah,S. H. |
| Nicotine is the most important alkaloid compound in tobacco. One of the major effects of nicotine is stimulation of mesocorticolimbic system. Prefrontal cortex plays a pivotal role in personality and mental state. It is considered the main cause of addiction as it is located in mesocorticolimbic dopamine system. Twenty four male rats were divided into four groups based on nicotine administration dose (0, 0.5, 1 and 1.5 g/kg). After animals were anesthetized, their brains were fixed using transcardiac method. Tissue processing and Golgi staining were performed and the stained tissue sections were analyzed by optic microscope and Motic software. By increasing the dose, nicotine significantly decreased the number of neuronal processes. In the higher dose,... |
| Tipo: Journal article |
Palavras-chave: Morphometric; Prefrontal cortex; Nicotine; Rat. |
| Ano: 2014 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300003 |
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