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Augmented cytotoxic, mutagenic and genotoxic response triggered by carvedilol and celecoxib combinations BJPS
Attiq,Ali; Ashraf,Muhammad; Jalil,Juriyati; Javeed,Aqeel; Anjum,Aftab Ahmad; Ullah,Asad; Umair,Muhammad; Ali,Sarwat.
Abstract It is understood that drugs regardless of their order of administration can exhibit drug interactions. Established on the fact that treatment of hypertension may last for decades and prolong usage of multiple drug regimen may induce substantial pathophysiological changes. Hence, This study was designed to evaluate the possible synergistic toxic effects of anti-hypertensive (carvedilol), and anti-inflammatory drug (celecoxib) alone and in combinations. Well-established MTT assay, Single Cell Gel Electrophoresis (SCGE) and Ames assay were employed to evaluate the toxicity at cellular level. Results from MTT assay on Vero cell line revealed that drug combinations have more pronounced anti-proliferative activity with combine IC50 value of 13.7:47.8...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Carvedilol; Celecoxib; Mutagenicity; Genotoxicity; Cytotoxicity..
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100622
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Evaluation of immunomodulatory effects of lomefloxacin in mice BJPS
Majeed,Arfa; Javeed,Aqeel; Omer,Muhammad Ovais; Mushtaq,Muhammad Hassan; Sattar,Adeel.
Lomefloxacin is a flouroquinolone antibiotic that is quite efficacious against many gram negative and gram positive pathogens. Lomefloxacin evince antibacterial effects by modifying DNA gyrase in gram negative pathogens and topoisomerase IV in gram positive pathogens. This study is designed to assess the immunomodulatory effects of lomefloxacin in male albino mice. Three doses of lomefloxacin 12.5 mg/kg, 25 mg/kg and 50 mg/kg were used and delayed type hypersensitivity assay, cyclophosphamide induced neutropenic assay, carbon clearance assay, heamagglutination assay and mice lethality test were performed to evaluate the effects of lomefloxacin on immune system of mice. DTH assay has depicted the significant immunosuppressant potential of lomefloxacin at 25...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cell-mediated; Humoral; Immunomodulatory; Immune response; Lomefloxacin.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100628
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