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	Provedor de dados Nature Precedings (1) Autor Andras Kapus (1) Emmanuel Battisti-Charbonney (1) Jean Parodo (1) Jennifer Tsang (1) John C. Marshall (1) Ori D. Rotstein (1) Sangyang Jia (1) Songhui Jia (1) Mais... Palavra-chave Immunology (1) Tipo do documento Manuscript (1) Ano 2011 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Circulating Neutrophils from Trauma Patients Induce Apoptosis Through Dephosphorylation of Epithelial Cell Caspase-8 Nature Precedings Songhui Jia; Jean Parodo; Emmanuel Battisti-Charbonney; Jennifer Tsang; Sangyang Jia; Ori D. Rotstein; Andras Kapus; John C. Marshall. Activated neutrophils can cause oxidant-mediated bystander injury to host cells. This injury has previously been ascribed to the direct effects of oxidants on membrane phospholipids. We show here that oxidants released by neutrophils activated in vivo in survivors of multiple trauma or in vitro by exposure to bacterial lipopolysaccharide (LPS) can also promote the apoptotic death of epithelial cells, through the SHP-1-mediated dephosphorylation of epithelial cell caspase-8. Neutrophils from a cohort of patients who sustained serious injury induced the apoptotic death of cultured epithelial cells in a manner that was dependent on the activity of the NADPH oxidase and the generation of neutrophil-derived reactive oxygen intermediates. Caspase-8 is... Tipo: Manuscript Palavras-chave: Immunology. Ano: 2011 URL: http://precedings.nature.com/documents/6393/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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