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	Provedor de dados BJPS (2) Autor Cao,Guangxiang (2) Jin,Xiaoqing (2) Zhong,Chuanqing (2) Chen,Yuguo (1) Wang,Fengshan (1) Wang,Liang (1) Zhang,Xiaoxiao (1) Mais... Palavra-chave Clavulanic acid (1) Clavulanic acid/formation of the Related substance E (1) High Performance Liquid Chromatography-Mass Spectrometry-Mass Spectrometry (1) Potassium clavulanate (1) Potassium clavulanate/production (1) Related substance E/formation (1) Related substance E/forming mechanism High performance liquid chromatography/biotechnological process (1) Related substance G (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2015 (1) 2014 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Studies on the formation and synthetic mechanism of related substance G in potassium clavulanate production BJPS Jin,Xiaoqing; Cao,Guangxiang; Zhang,Xiaoxiao; Chen,Yuguo; Wang,Liang; Zhong,Chuanqing. The objective of this study was to investigate the formation and synthetic mechanism of related substance G in potassium clavulanate production. The impurity in the potassium clavulanate final product, with a retention time of 13.5 min, was confirmed as related substance G by high performance liquid chromatography-mass spectrometry/mass spectrometry. Related substance G analysis during the production of clavulanic acid showed that this impurity could be synthesized during fermentation, and the amount increased with the fermentation time. Studies on its synthetic mechanism showed that L-tyrosine and succinic acid were the precursors for biosynthesis of related substance G in vivo. The reaction was deduced to be catalyzed by an enzyme. The enzyme was a type... Tipo: Info:eu-repo/semantics/article Palavras-chave: Potassium clavulanate; Clavulanic acid; Related substance G; Related substance G; High Performance Liquid Chromatography-Mass Spectrometry-Mass Spectrometry. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100077 Studies on the formation and forming mechanism of the related substance E in potassium clavulanate production by HPLC-MS/MS BJPS Zhong,Chuanqing; Cao,Guangxiang; Jin,Xiaoqing; Wang,Fengshan. The objective of this study was to investigate the formation and forming mechanism of the related substance E in potassium clavulanate production. The impurity with retention time of 11.1 min in potassium clavulanate final product was confirmed as the related substance E by high performance liquid chromatography with tandem mass spectrometric detection (HPLC-MS/MS).The related substance E analysis during the production of clavulanic acid showed that this impurity could be formed during both the fermentation and purification processes, especially in the later fermentation stage, filtration concentration and back-extraction procedure. Clavulanic acid was the precursor of the related substance E. Studies on its forming mechanism showed that the related... Tipo: Info:eu-repo/semantics/article Palavras-chave: Potassium clavulanate/production; Clavulanic acid/formation of the Related substance E; Related substance E/formation; Related substance E/forming mechanism High performance liquid chromatography/biotechnological process. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200391 Registros recuperados: 2 Primeira ... 1 ... Última

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